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The bottom line is to always consult your doctor first if you’d like to try CBD, especially if you have a health condition and are taking medications. Don’t stop taking your prescription medications to try CBD, unless you have the go-ahead from your doctor. More than 85 drugs interact with grapefruit and some closely related citrus juices — like Seville oranges, pomelos, and tangelos. That’s because chemicals in grapefruit known as furanocoumarins inhibit CYP3A4, in a similar fashion as CBD. According to the Food and Drug Administration, consuming grapefruit while on one of these medications can lead to a higher concentration of the medication in the bloodstream and adverse side effects or even an overdose.